Drug interactions
Cimetidine + Dasatinib
Severity: Major
Cimetidine and Dasatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine can raise dasatinib exposure through CYP3A4 inhibition, but as an H2 blocker it also lowers gastric acidity, which reduces dasatinib absorption because its solubility depends on acid. The net effect is unpredictable and may result in either toxicity or reduced efficacy.
What this interaction means in plain words
Cimetidine and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cimetidine belongs to Gastrointestinal Tract; Dasatinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by cimetidine may increase dasatinib levels, while the rise in gastric pH decreases dasatinib dissolution and absorption.
What to do
Avoid H2 blockers with dasatinib; use an antacid given at least 2 hours before or after dasatinib if acid suppression is needed. Monitor response and toxicity if combination cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Cimetidine with Dasatinib?
MediHelp rates the interaction as major. Cimetidine and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cimetidine can raise dasatinib exposure through CYP3A4 inhibition, but as an H2 blocker it also lowers gastric acidity, which reduces dasatinib absorption because its solubility depends on acid. The net effect is unpredictable and may result in either toxicity or reduced efficacy.
How serious is the interaction between Cimetidine and Dasatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid H2 blockers with dasatinib; use an antacid given at least 2 hours before or after dasatinib if acid suppression is needed. Monitor response and toxicity if combination cannot be avoided.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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