Interazioni tra farmaci
Clomipramine + Pefloxacin
Gravità: Moderata
Clomipramine and Pefloxacin: moderate interaction.
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Sintesi
Pefloxacin inhibits CYP1A2, one of the pathways metabolising clomipramine, so levels may rise and cause tricyclic adverse effects. Fluoroquinolones can also prolong the QT interval and lower the seizure threshold.
Cosa significa questa interazione in parole semplici
Clomipramine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Pefloxacin belongs to Anti Bacterial.
Perché avviene
CYP1A2 inhibition by pefloxacin reduces clomipramine clearance, with additive QT and seizure-threshold effects.
Cosa fare
Monitor for anticholinergic, cardiac and neurological toxicity and consider an ECG; choose a non-quinolone antibiotic if possible.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Clomipramine
- Arsenic trioxide + Clomipramine Controindicata
- Clomipramine + Dofetilide Controindicata
- Clomipramine + Droperidol Controindicata
- Clomipramine + Isocarboxazid Controindicata
- Clomipramine + Methylene blue Controindicata
- Clomipramine + Pentamidine Controindicata
Altre interazioni di Pefloxacin
- Pefloxacin + Tizanidine Controindicata
- Clozapine + Pefloxacin Maggiore
- Duloxetine + Pefloxacin Maggiore
- Pefloxacin + Theophylline Maggiore
- Asenapine + Pefloxacin Moderata
- Caffeine + Pefloxacin Moderata
Domande frequenti
Can I take Clomipramine with Pefloxacin?
MediHelp rates the interaction as moderate. Clomipramine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pefloxacin inhibits CYP1A2, one of the pathways metabolising clomipramine, so levels may rise and cause tricyclic adverse effects. Fluoroquinolones can also prolong the QT interval and lower the seizure threshold.
How serious is the interaction between Clomipramine and Pefloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic, cardiac and neurological toxicity and consider an ECG; choose a non-quinolone antibiotic if possible.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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