Vai al contenuto
MediHelp
MediHelp Riferimento sui farmaci

Interazioni tra farmaci

Cyclosporin + Griseofulvin

Gravità: Maggiore

Cyclosporin and Griseofulvin: major interaction.

Ultimo aggiornamento

Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.

Il contenuto clinico di questa pagina è disponibile solo in inglese.

Sintesi

Griseofulvin can lower cyclosporine blood concentrations, and this has been associated with loss of immunosuppression and graft rejection in case reports. The effect may develop over days to weeks and can persist after griseofulvin is stopped.

Cosa significa questa interazione in parole semplici

Cyclosporin and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cyclosporin belongs to Miscellaneous; Griseofulvin belongs to Anti Fungals.

Livello di evidenza: Low

Perché avviene

Griseofulvin induces hepatic and intestinal CYP3A4, accelerating cyclosporine metabolism.

Cosa fare

Avoid the combination in transplant patients where possible and consider an alternative antifungal such as terbinafine. If it is unavoidable, monitor cyclosporine trough levels frequently and increase the dose as needed.

Cosa chiedere al farmacista

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Per gli utenti Pro+

Sblocca la pagina completa

Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Cyclosporin e Griseofulvin, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
Crea un account gratuito Accedi

Provi Pro+ gratis per 7 giorni sul web. Nessuna carta.

Domande frequenti

Can I take Cyclosporin with Griseofulvin?

MediHelp rates the interaction as major. Cyclosporin and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Griseofulvin can lower cyclosporine blood concentrations, and this has been associated with loss of immunosuppression and graft rejection in case reports. The effect may develop over days to weeks and can persist after griseofulvin is stopped.

How serious is the interaction between Cyclosporin and Griseofulvin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in transplant patients where possible and consider an alternative antifungal such as terbinafine. If it is unavoidable, monitor cyclosporine trough levels frequently and increase the dose as needed.

What other medicines interact with Cyclosporin?

MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.

Monografie complete, posologie e verifica delle interazioni nell'app MediHelp

Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.

Scarica suApp Store Disponibile suGoogle Play

Sfoglia dalla A alla Z · Interazioni tra farmaci

Scarica l'app Accedi