Interazioni tra farmaci
Cyclosporin + Red yeast rice
Gravità: Maggiore
Cyclosporin and Red yeast rice: major interaction.
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Sintesi
Red yeast rice contains monacolin K, chemically identical to lovastatin, so cyclosporine can raise statin exposure and the risk of myopathy and rhabdomyolysis. Product content is variable and unregulated, which makes the exposure unpredictable.
Cosa significa questa interazione in parole semplici
Cyclosporin and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Red yeast rice belongs to Gastrointestinal Tract.
Perché avviene
Cyclosporine inhibits CYP3A4 and OATP-mediated disposition of monacolin K (lovastatin), increasing its systemic levels.
Cosa fare
Avoid red yeast rice in patients taking cyclosporine and use a prescribed statin with labeled dose limits if lipid lowering is needed. Report muscle pain or dark urine promptly.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Controindicata
- Aliskiren + Cyclosporin Controindicata
- Bcg vaccine live + Cyclosporin Controindicata
- Bosentan + Cyclosporin Controindicata
- Cidofovir + Cyclosporin Controindicata
- Cyclosporin + Dengue vaccine Controindicata
Altre interazioni di Red yeast rice
- Red yeast rice + Ritonavir Controindicata
- Red yeast rice + Saquinavir Controindicata
- Red yeast rice + Tipranavir Controindicata
- Atazanavir + Red yeast rice Maggiore
- Atorvastatin + Red yeast rice Maggiore
- Conivaptan + Red yeast rice Maggiore
Domande frequenti
Can I take Cyclosporin with Red yeast rice?
MediHelp rates the interaction as major. Cyclosporin and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Red yeast rice contains monacolin K, chemically identical to lovastatin, so cyclosporine can raise statin exposure and the risk of myopathy and rhabdomyolysis. Product content is variable and unregulated, which makes the exposure unpredictable.
How serious is the interaction between Cyclosporin and Red yeast rice?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid red yeast rice in patients taking cyclosporine and use a prescribed statin with labeled dose limits if lipid lowering is needed. Report muscle pain or dark urine promptly.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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