Interazioni tra farmaci
Dihydroergotamine + Erythromycin lactobionate
Gravità: Controindicata
Dihydroergotamine and Erythromycin lactobionate: contraindicated interaction.
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Sintesi
Erythromycin raises dihydroergotamine concentrations, which can cause ergotism with severe peripheral and cerebral vasospasm and ischemia. Cases of limb and organ ischemia have been reported with CYP3A4 inhibitors and ergots.
Cosa significa questa interazione in parole semplici
Dihydroergotamine and Erythromycin lactobionate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dihydroergotamine belongs to Central Nervous System; Erythromycin lactobionate belongs to Anti Bacterial.
Perché avviene
Erythromycin inhibits CYP3A4-mediated metabolism of dihydroergotamine.
Cosa fare
Do not use together; choose a non-macrolide antibiotic such as one without CYP3A4 inhibition, or another migraine therapy.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Controindicata
- Dronedarone + Erythromycin lactobionate Controindicata
- Eletriptan + Erythromycin lactobionate Controindicata
- Ergotamine + Erythromycin lactobionate Controindicata
- Erythromycin lactobionate + Flibanserin Controindicata
- Erythromycin lactobionate + Lovastatin Controindicata
Altre interazioni di Dihydroergotamine
- Almotriptan + Dihydroergotamine Controindicata
- Clarithromycin + Dihydroergotamine Controindicata
- Dihydroergotamine + Dopamine Controindicata
- Dihydroergotamine + Dronedarone Controindicata
- Dihydroergotamine + Efavirenz Controindicata
- Dihydroergotamine + Eletriptan Controindicata
Domande frequenti
Can I take Dihydroergotamine with Erythromycin lactobionate?
MediHelp rates the interaction as contraindicated. Dihydroergotamine and Erythromycin lactobionate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Erythromycin raises dihydroergotamine concentrations, which can cause ergotism with severe peripheral and cerebral vasospasm and ischemia. Cases of limb and organ ischemia have been reported with CYP3A4 inhibitors and ergots.
How serious is the interaction between Dihydroergotamine and Erythromycin lactobionate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose a non-macrolide antibiotic such as one without CYP3A4 inhibition, or another migraine therapy.
What other medicines interact with Erythromycin lactobionate?
MediHelp also lists interactions of Erythromycin lactobionate with, for example, Cisapride, Dronedarone, Eletriptan. The full list is on the Erythromycin lactobionate page.
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