Interazioni tra farmaci
Ergotamine + Erythromycin lactobionate
Gravità: Controindicata
Ergotamine and Erythromycin lactobionate: contraindicated interaction.
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Sintesi
Intravenous erythromycin markedly raises ergotamine exposure, and this has led to acute ergotism with severe vasospasm and ischemia. Ergotamine labeling contraindicates its use with macrolide antibiotics.
Cosa significa questa interazione in parole semplici
Ergotamine and Erythromycin lactobionate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ergotamine belongs to Central Nervous System; Erythromycin lactobionate belongs to Anti Bacterial.
Perché avviene
Erythromycin inhibits CYP3A4-mediated metabolism of ergotamine, increasing its systemic concentrations.
Cosa fare
Do not co-administer; withhold ergotamine while erythromycin is given or select a different antibiotic. Monitor for signs of peripheral ischemia if exposure occurs.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Ergotamine
- Almotriptan + Ergotamine Controindicata
- Atazanavir + Ergotamine Controindicata
- Clarithromycin + Ergotamine Controindicata
- Cobicistat + Ergotamine Controindicata
- Darunavir + Ergotamine Controindicata
- Dihydroergotamine intranasal + Ergotamine Controindicata
Altre interazioni di Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Controindicata
- Dihydroergotamine + Erythromycin lactobionate Controindicata
- Dronedarone + Erythromycin lactobionate Controindicata
- Eletriptan + Erythromycin lactobionate Controindicata
- Erythromycin lactobionate + Flibanserin Controindicata
- Erythromycin lactobionate + Lovastatin Controindicata
Domande frequenti
Can I take Ergotamine with Erythromycin lactobionate?
MediHelp rates the interaction as contraindicated. Ergotamine and Erythromycin lactobionate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Intravenous erythromycin markedly raises ergotamine exposure, and this has led to acute ergotism with severe vasospasm and ischemia. Ergotamine labeling contraindicates its use with macrolide antibiotics.
How serious is the interaction between Ergotamine and Erythromycin lactobionate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; withhold ergotamine while erythromycin is given or select a different antibiotic. Monitor for signs of peripheral ischemia if exposure occurs.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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