Interazioni tra farmaci
Disopyramide + Moxifloxacin
Gravità: Controindicata
Disopyramide and Moxifloxacin: contraindicated interaction.
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Sintesi
Both drugs prolong the QT interval, and combined use raises the risk of torsades de pointes and other serious ventricular arrhythmias. Disopyramide is a class Ia antiarrhythmic with notable proarrhythmic potential.
Cosa significa questa interazione in parole semplici
Disopyramide and Moxifloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Disopyramide belongs to Cardiovascular; Moxifloxacin belongs to Anti Bacterial.
Perché avviene
Additive blockade of cardiac potassium channels (hERG) causing delayed repolarization and QT prolongation.
Cosa fare
Avoid the combination and choose a non-QT-prolonging antibacterial such as a beta-lactam. If unavoidable, ECG and electrolyte monitoring are essential.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Moxifloxacin
- Amiodarone + Moxifloxacin Controindicata
- Arsenic trioxide + Moxifloxacin Controindicata
- Dofetilide + Moxifloxacin Controindicata
- Dronedarone + Moxifloxacin Controindicata
- Droperidol + Moxifloxacin Controindicata
- Ibutilide + Moxifloxacin Controindicata
Altre interazioni di Disopyramide
- Amisulpride + Disopyramide Controindicata
- Desipramine + Disopyramide Controindicata
- Disopyramide + Dronedarone Controindicata
- Disopyramide + Itraconazole Controindicata
- Disopyramide + Ketoconazole Controindicata
- Disopyramide + Maprotiline Controindicata
Domande frequenti
Can I take Disopyramide with Moxifloxacin?
MediHelp rates the interaction as contraindicated. Disopyramide and Moxifloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and combined use raises the risk of torsades de pointes and other serious ventricular arrhythmias. Disopyramide is a class Ia antiarrhythmic with notable proarrhythmic potential.
How serious is the interaction between Disopyramide and Moxifloxacin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging antibacterial such as a beta-lactam. If unavoidable, ECG and electrolyte monitoring are essential.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Dofetilide. The full list is on the Moxifloxacin page.
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