Interazioni tra farmaci
Duloxetine + Linezolid
Gravità: Controindicata
Duloxetine and Linezolid: contraindicated interaction.
Ultimo aggiornamento Fonti: US FDA label
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Sintesi
Linezolid is a weak reversible nonselective MAO inhibitor, and combining it with duloxetine can cause serotonin syndrome. Features include agitation, confusion, tremor, clonus, hyperreflexia, sweating and fever, and the condition can be life threatening. Duloxetine labeling restricts its use with linezolid except in emergencies where benefits outweigh the risk.
Cosa significa questa interazione in parole semplici
Duloxetine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Duloxetine belongs to Central Nervous System; Linezolid belongs to Anti Bacterial.
Perché avviene
Linezolid inhibits MAO and reduces serotonin breakdown, while duloxetine blocks serotonin and norepinephrine reuptake, producing excessive serotonergic stimulation.
Cosa fare
Avoid the combination and choose an alternative antibiotic where possible. If linezolid is urgently required, stop duloxetine and monitor for serotonin toxicity for about 2 weeks or until 24 hours after the last linezolid dose, whichever comes first.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Riferimenti
Altre interazioni di Duloxetine
- Duloxetine + Isocarboxazid Controindicata
- Duloxetine + Methylene blue Controindicata
- Duloxetine + Phenelzine Controindicata
- Duloxetine + Procarbazine Controindicata
- Duloxetine + Rasagiline Controindicata
- Duloxetine + Safinamide Controindicata
Altre interazioni di Linezolid
- Amoxapine + Linezolid Controindicata
- Atomoxetine + Linezolid Controindicata
- Benzphetamine + Linezolid Controindicata
- Brimonidine + Linezolid Controindicata
- Bupropion-naltrexone + Linezolid Controindicata
- Bupropion + Linezolid Controindicata
Domande frequenti
Can I take Duloxetine with Linezolid?
MediHelp rates the interaction as contraindicated. Duloxetine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Linezolid is a weak reversible nonselective MAO inhibitor, and combining it with duloxetine can cause serotonin syndrome. Features include agitation, confusion, tremor, clonus, hyperreflexia, sweating and fever, and the condition can be life threatening. Duloxetine labeling restricts its use with linezolid except in emergencies where benefits outweigh the risk.
How serious is the interaction between Duloxetine and Linezolid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative antibiotic where possible. If linezolid is urgently required, stop duloxetine and monitor for serotonin toxicity for about 2 weeks or until 24 hours after the last linezolid dose, whichever comes first.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Duloxetine page.
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