Interazioni tra farmaci
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Ergotamine
Gravità: Controindicata
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ergotamine: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
The cobicistat component strongly inhibits CYP3A4 and can sharply raise ergotamine concentrations. This can precipitate acute ergotism with severe peripheral vasospasm and ischemia.
Cosa significa questa interazione in parole semplici
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Cobicistat inhibits CYP3A4-mediated ergotamine metabolism.
Cosa fare
Do not co-administer. Use a non-ergot migraine therapy during treatment with this regimen.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Ergotamine
- Almotriptan + Ergotamine Controindicata
- Atazanavir + Ergotamine Controindicata
- Clarithromycin + Ergotamine Controindicata
- Cobicistat + Ergotamine Controindicata
- Darunavir + Ergotamine Controindicata
- Dihydroergotamine intranasal + Ergotamine Controindicata
Domande frequenti
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Ergotamine?
MediHelp rates the interaction as contraindicated. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The cobicistat component strongly inhibits CYP3A4 and can sharply raise ergotamine concentrations. This can precipitate acute ergotism with severe peripheral vasospasm and ischemia.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ergotamine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Use a non-ergot migraine therapy during treatment with this regimen.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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