Interazioni tra farmaci
Ephedrine + Phenelzine
Gravità: Controindicata
Ephedrine and Phenelzine: contraindicated interaction.
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Sintesi
Ephedrine releases norepinephrine, and MAO inhibitors greatly enhance this effect. Hypertensive crisis with severe headache and possible stroke can occur.
Cosa significa questa interazione in parole semplici
Ephedrine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ephedrine belongs to Cardiovascular; Phenelzine belongs to Central Nervous System.
Perché avviene
MAO inhibition prevents norepinephrine breakdown, amplifying the indirect sympathomimetic action of ephedrine.
Cosa fare
Avoid ephedrine and ephedrine-containing products during phenelzine therapy and for 14 days after. If a pressor is needed in emergencies, use a direct-acting agent at reduced dose with close monitoring.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Phenelzine
- 5-HTP + Phenelzine Controindicata
- Amitriptyline + Phenelzine Controindicata
- Amoxapine + Phenelzine Controindicata
- Atomoxetine + Phenelzine Controindicata
- Benzphetamine + Phenelzine Controindicata
- Brimonidine + Phenelzine Controindicata
Altre interazioni di Ephedrine
- Ephedrine + Isocarboxazid Controindicata
- Ephedrine + Procarbazine Controindicata
- Ephedrine + Rasagiline Controindicata
- Ephedrine + Selegiline Controindicata
- Ephedrine + Tranylcypromine Controindicata
- Caffeine + Ephedrine Maggiore
Domande frequenti
Can I take Ephedrine with Phenelzine?
MediHelp rates the interaction as contraindicated. Ephedrine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ephedrine releases norepinephrine, and MAO inhibitors greatly enhance this effect. Hypertensive crisis with severe headache and possible stroke can occur.
How serious is the interaction between Ephedrine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ephedrine and ephedrine-containing products during phenelzine therapy and for 14 days after. If a pressor is needed in emergencies, use a direct-acting agent at reduced dose with close monitoring.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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