Interazioni tra farmaci
Ephedrine + Selegiline
Gravità: Controindicata
Ephedrine and Selegiline: contraindicated interaction.
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Sintesi
Ephedrine in a patient on an MAO inhibitor may produce a markedly exaggerated pressor response and hypertensive crisis. Indirect sympathomimetics are contraindicated with MAOIs.
Cosa significa questa interazione in parole semplici
Ephedrine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ephedrine belongs to Cardiovascular; Selegiline belongs to Central Nervous System.
Perché avviene
Ephedrine releases norepinephrine from nerve terminals, and MAO inhibition prevents its breakdown, so catecholamines accumulate.
Cosa fare
Avoid ephedrine during and for 14 days after selegiline. Use a non-sympathomimetic alternative, and treat any hypertensive emergency promptly.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Selegiline
- Amitriptyline + Selegiline Controindicata
- Amoxapine + Selegiline Controindicata
- Atomoxetine + Selegiline Controindicata
- Benzphetamine + Selegiline Controindicata
- Brimonidine + Selegiline Controindicata
- Buprenorphine long-acting + Selegiline Controindicata
Altre interazioni di Ephedrine
- Ephedrine + Isocarboxazid Controindicata
- Ephedrine + Phenelzine Controindicata
- Ephedrine + Procarbazine Controindicata
- Ephedrine + Rasagiline Controindicata
- Ephedrine + Tranylcypromine Controindicata
- Caffeine + Ephedrine Maggiore
Domande frequenti
Can I take Ephedrine with Selegiline?
MediHelp rates the interaction as contraindicated. Ephedrine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ephedrine in a patient on an MAO inhibitor may produce a markedly exaggerated pressor response and hypertensive crisis. Indirect sympathomimetics are contraindicated with MAOIs.
How serious is the interaction between Ephedrine and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ephedrine during and for 14 days after selegiline. Use a non-sympathomimetic alternative, and treat any hypertensive emergency promptly.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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