Interazioni tra farmaci
Ephedrine + Isocarboxazid
Gravità: Controindicata
Ephedrine and Isocarboxazid: contraindicated interaction.
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Sintesi
Ephedrine with an MAOI can cause severe hypertension and hypertensive crisis. Effects can be markedly greater than expected.
Cosa significa questa interazione in parole semplici
Ephedrine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ephedrine belongs to Cardiovascular; Isocarboxazid belongs to Central Nervous System.
Perché avviene
Ephedrine releases norepinephrine from nerve terminals that are loaded because of MAO inhibition, and metabolism is reduced, producing exaggerated pressor effects.
Cosa fare
Avoid ephedrine, including in cold remedies, during and for 14 days after MAOI therapy. If a vasopressor is needed perioperatively, use a direct-acting agent in carefully titrated small doses with close monitoring.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Isocarboxazid
- 5-HTP + Isocarboxazid Controindicata
- Amitriptyline + Isocarboxazid Controindicata
- Amobarbital + Isocarboxazid Controindicata
- Amoxapine + Isocarboxazid Controindicata
- Apraclonidine + Isocarboxazid Controindicata
- Atomoxetine + Isocarboxazid Controindicata
Altre interazioni di Ephedrine
- Ephedrine + Phenelzine Controindicata
- Ephedrine + Procarbazine Controindicata
- Ephedrine + Rasagiline Controindicata
- Ephedrine + Selegiline Controindicata
- Ephedrine + Tranylcypromine Controindicata
- Caffeine + Ephedrine Maggiore
Domande frequenti
Can I take Ephedrine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Ephedrine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ephedrine with an MAOI can cause severe hypertension and hypertensive crisis. Effects can be markedly greater than expected.
How serious is the interaction between Ephedrine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ephedrine, including in cold remedies, during and for 14 days after MAOI therapy. If a vasopressor is needed perioperatively, use a direct-acting agent in carefully titrated small doses with close monitoring.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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