Interazioni tra farmaci
Ephedrine + Rasagiline
Gravità: Controindicata
Ephedrine and Rasagiline: contraindicated interaction.
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Sintesi
Ephedrine releases norepinephrine and its pressor effect can be strongly potentiated by MAO inhibitors. This risks a hypertensive crisis.
Cosa significa questa interazione in parole semplici
Ephedrine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ephedrine belongs to Cardiovascular; Rasagiline belongs to Central Nervous System.
Perché avviene
MAO inhibition increases neuronal norepinephrine stores and reduces metabolism, amplifying indirect sympathomimetic action of ephedrine.
Cosa fare
Avoid ephedrine in patients on rasagiline. If a vasopressor is required in the perioperative setting, use a cautiously titrated direct-acting agent with close blood pressure monitoring.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Rasagiline
- Atomoxetine + Rasagiline Controindicata
- Brimonidine + Rasagiline Controindicata
- Bupropion-naltrexone + Rasagiline Controindicata
- Bupropion + Rasagiline Controindicata
- Clomipramine + Rasagiline Controindicata
- Desvenlafaxine + Rasagiline Controindicata
Altre interazioni di Ephedrine
- Ephedrine + Isocarboxazid Controindicata
- Ephedrine + Phenelzine Controindicata
- Ephedrine + Procarbazine Controindicata
- Ephedrine + Selegiline Controindicata
- Ephedrine + Tranylcypromine Controindicata
- Caffeine + Ephedrine Maggiore
Domande frequenti
Can I take Ephedrine with Rasagiline?
MediHelp rates the interaction as contraindicated. Ephedrine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ephedrine releases norepinephrine and its pressor effect can be strongly potentiated by MAO inhibitors. This risks a hypertensive crisis.
How serious is the interaction between Ephedrine and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ephedrine in patients on rasagiline. If a vasopressor is required in the perioperative setting, use a cautiously titrated direct-acting agent with close blood pressure monitoring.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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