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Everolimus + Levoketoconazole

Gravità: Controindicata

Everolimus and Levoketoconazole: contraindicated interaction.

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Sintesi

Levoketoconazole is a strong CYP3A4 and P-glycoprotein inhibitor and is expected to markedly raise everolimus concentrations. Higher exposure increases the risk of serious adverse effects including infections, stomatitis, pneumonitis and metabolic disturbances.

Cosa significa questa interazione in parole semplici

Everolimus and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Everolimus belongs to Oncology; Levoketoconazole belongs to Endocrine.

Livello di evidenza: High

Perché avviene

Strong inhibition of CYP3A4 and P-glycoprotein by levoketoconazole reduces everolimus clearance.

Cosa fare

Avoid the combination; use an alternative to levoketoconazole or everolimus. Strong inhibitors such as ketoconazole are to be avoided with everolimus per labeling.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Everolimus with Levoketoconazole?

MediHelp rates the interaction as contraindicated. Everolimus and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole is a strong CYP3A4 and P-glycoprotein inhibitor and is expected to markedly raise everolimus concentrations. Higher exposure increases the risk of serious adverse effects including infections, stomatitis, pneumonitis and metabolic disturbances.

How serious is the interaction between Everolimus and Levoketoconazole?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative to levoketoconazole or everolimus. Strong inhibitors such as ketoconazole are to be avoided with everolimus per labeling.

What other medicines interact with Everolimus?

MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Everolimus page.

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