Interazioni tra farmaci
Fezolinetant + Fluvoxamine
Gravità: Controindicata
Fezolinetant and Fluvoxamine: contraindicated interaction.
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Sintesi
Fezolinetant is metabolised mainly by CYP1A2, and fluvoxamine is a strong CYP1A2 inhibitor that greatly increases its exposure. This raises the risk of adverse effects including hepatotoxicity.
Cosa significa questa interazione in parole semplici
Fezolinetant and Fluvoxamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fezolinetant belongs to Endocrine; Fluvoxamine belongs to Central Nervous System.
Perché avviene
Strong CYP1A2 inhibition by fluvoxamine markedly reduces fezolinetant clearance.
Cosa fare
Do not use together; choose a different antidepressant or vasomotor symptom treatment. If fezolinetant is used, monitor liver tests per labeling.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Fluvoxamine
- Agomelatine + Fluvoxamine Controindicata
- Alosetron + Fluvoxamine Controindicata
- Fluvoxamine + Isocarboxazid Controindicata
- Fluvoxamine + Mavacamten Controindicata
- Fluvoxamine + Methylene blue Controindicata
- Fluvoxamine + Phenelzine Controindicata
Altre interazioni di Fezolinetant
- Cimetidine + Fezolinetant Controindicata
- Ciprofloxacin + Fezolinetant Controindicata
- Desogestrel-ethinyl estradiol + Fezolinetant Controindicata
- Estradiol + Fezolinetant Controindicata
- Ethinyl estradiol-drospirenone + Fezolinetant Controindicata
- Ethinyl estradiol-levonorgestrel + Fezolinetant Controindicata
Domande frequenti
Can I take Fezolinetant with Fluvoxamine?
MediHelp rates the interaction as contraindicated. Fezolinetant and Fluvoxamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fezolinetant is metabolised mainly by CYP1A2, and fluvoxamine is a strong CYP1A2 inhibitor that greatly increases its exposure. This raises the risk of adverse effects including hepatotoxicity.
How serious is the interaction between Fezolinetant and Fluvoxamine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose a different antidepressant or vasomotor symptom treatment. If fezolinetant is used, monitor liver tests per labeling.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Isocarboxazid. The full list is on the Fluvoxamine page.
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