Interazioni tra farmaci
Fluvoxamine + Isocarboxazid
Gravità: Controindicata
Fluvoxamine and Isocarboxazid: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Isocarboxazid irreversibly inhibits monoamine oxidase, so serotonin is not broken down, and fluvoxamine is an SSRI that increases synaptic serotonin. Together they can precipitate serotonin syndrome with hyperthermia, agitation, clonus and autonomic instability, which can be fatal.
Cosa significa questa interazione in parole semplici
Fluvoxamine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluvoxamine belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.
Perché avviene
Excess serotonergic activity (MAO inhibition plus serotonin reuptake or receptor effects)
Cosa fare
Do not co-administer. Leave at least 14 days after stopping isocarboxazid before starting fluvoxamine, and at least 14 days after stopping fluvoxamine before starting isocarboxazid.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Fluvoxamine
- Agomelatine + Fluvoxamine Controindicata
- Alosetron + Fluvoxamine Controindicata
- Fezolinetant + Fluvoxamine Controindicata
- Fluvoxamine + Mavacamten Controindicata
- Fluvoxamine + Methylene blue Controindicata
- Fluvoxamine + Phenelzine Controindicata
Altre interazioni di Isocarboxazid
- 5-HTP + Isocarboxazid Controindicata
- Amitriptyline + Isocarboxazid Controindicata
- Amobarbital + Isocarboxazid Controindicata
- Amoxapine + Isocarboxazid Controindicata
- Apraclonidine + Isocarboxazid Controindicata
- Atomoxetine + Isocarboxazid Controindicata
Domande frequenti
Can I take Fluvoxamine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Fluvoxamine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isocarboxazid irreversibly inhibits monoamine oxidase, so serotonin is not broken down, and fluvoxamine is an SSRI that increases synaptic serotonin. Together they can precipitate serotonin syndrome with hyperthermia, agitation, clonus and autonomic instability, which can be fatal.
How serious is the interaction between Fluvoxamine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Leave at least 14 days after stopping isocarboxazid before starting fluvoxamine, and at least 14 days after stopping fluvoxamine before starting isocarboxazid.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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