Interazioni tra farmaci
Ketoconazole + Venetoclax
Gravità: Controindicata
Ketoconazole and Venetoclax: contraindicated interaction.
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Sintesi
Ketoconazole markedly raises venetoclax exposure, increasing the risk of tumor lysis syndrome and neutropenia. It is contraindicated during the initial ramp-up phase.
Cosa significa questa interazione in parole semplici
Ketoconazole and Venetoclax are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ketoconazole belongs to Anti Fungals; Venetoclax belongs to Miscellaneous.
Perché avviene
Strong CYP3A4 inhibition (and P-gp inhibition) reduces venetoclax clearance.
Cosa fare
Avoid during ramp-up. After ramp-up, reduce the venetoclax dose by at least 75% and monitor for toxicity.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Ketoconazole
- Alfuzosin + Ketoconazole Controindicata
- Alprazolam + Ketoconazole Controindicata
- Avanafil + Ketoconazole Controindicata
- Conivaptan + Ketoconazole Controindicata
- Dihydroergotamine intranasal + Ketoconazole Controindicata
- Dihydroergotamine + Ketoconazole Controindicata
Altre interazioni di Venetoclax
- Clarithromycin + Venetoclax Controindicata
- Itraconazole + Venetoclax Controindicata
- Posaconazole + Venetoclax Controindicata
- Venetoclax + Voriconazole Controindicata
- Amiodarone + Venetoclax Maggiore
- Apalutamide + Venetoclax Maggiore
Domande frequenti
Can I take Ketoconazole with Venetoclax?
MediHelp rates the interaction as contraindicated. Ketoconazole and Venetoclax are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole markedly raises venetoclax exposure, increasing the risk of tumor lysis syndrome and neutropenia. It is contraindicated during the initial ramp-up phase.
How serious is the interaction between Ketoconazole and Venetoclax?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during ramp-up. After ramp-up, reduce the venetoclax dose by at least 75% and monitor for toxicity.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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