Interazioni tra farmaci
Itraconazole + Venetoclax
Gravità: Controindicata
Itraconazole and Venetoclax: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Itraconazole increases venetoclax exposure and risks tumor lysis syndrome during dose initiation, as well as neutropenia and other toxicities. The risk is greatest during the ramp-up phase.
Cosa significa questa interazione in parole semplici
Itraconazole and Venetoclax are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Itraconazole belongs to Anti Fungals; Venetoclax belongs to Miscellaneous.
Perché avviene
Strong CYP3A4 inhibition (and P-glycoprotein inhibition) by itraconazole reduces venetoclax clearance.
Cosa fare
Do not use during venetoclax initiation and ramp-up; after ramp-up, reduce the venetoclax dose by at least 75% per labeling and monitor for toxicity and blood counts.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Itraconazole
- Alfuzosin + Itraconazole Controindicata
- Alprazolam + Itraconazole Controindicata
- Avanafil + Itraconazole Controindicata
- Conivaptan + Itraconazole Controindicata
- Dihydroergotamine intranasal + Itraconazole Controindicata
- Dihydroergotamine + Itraconazole Controindicata
Altre interazioni di Venetoclax
- Clarithromycin + Venetoclax Controindicata
- Ketoconazole + Venetoclax Controindicata
- Posaconazole + Venetoclax Controindicata
- Venetoclax + Voriconazole Controindicata
- Amiodarone + Venetoclax Maggiore
- Apalutamide + Venetoclax Maggiore
Domande frequenti
Can I take Itraconazole with Venetoclax?
MediHelp rates the interaction as contraindicated. Itraconazole and Venetoclax are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole increases venetoclax exposure and risks tumor lysis syndrome during dose initiation, as well as neutropenia and other toxicities. The risk is greatest during the ramp-up phase.
How serious is the interaction between Itraconazole and Venetoclax?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use during venetoclax initiation and ramp-up; after ramp-up, reduce the venetoclax dose by at least 75% per labeling and monitor for toxicity and blood counts.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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