Interazioni tra farmaci
Posaconazole + Venetoclax
Gravità: Controindicata
Posaconazole and Venetoclax: contraindicated interaction.
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Sintesi
Posaconazole significantly increases venetoclax exposure, raising the risk of tumor lysis syndrome during ramp-up and of neutropenia and other toxicity afterward.
Cosa significa questa interazione in parole semplici
Posaconazole and Venetoclax are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Posaconazole belongs to Anti Fungals; Venetoclax belongs to Miscellaneous.
Perché avviene
Posaconazole strongly inhibits CYP3A4 and may inhibit P-glycoprotein, reducing venetoclax clearance.
Cosa fare
Do not use during venetoclax initiation and ramp-up. After ramp-up, reduce the venetoclax dose per labeling (substantially) and monitor for toxicity and blood counts.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Posaconazole
- Artemether + Posaconazole Controindicata
- Avanafil + Posaconazole Controindicata
- Cobimetinib + Posaconazole Controindicata
- Conivaptan + Posaconazole Controindicata
- Dihydroergotamine intranasal + Posaconazole Controindicata
- Dihydroergotamine + Posaconazole Controindicata
Altre interazioni di Venetoclax
- Clarithromycin + Venetoclax Controindicata
- Itraconazole + Venetoclax Controindicata
- Ketoconazole + Venetoclax Controindicata
- Venetoclax + Voriconazole Controindicata
- Amiodarone + Venetoclax Maggiore
- Apalutamide + Venetoclax Maggiore
Domande frequenti
Can I take Posaconazole with Venetoclax?
MediHelp rates the interaction as contraindicated. Posaconazole and Venetoclax are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Posaconazole significantly increases venetoclax exposure, raising the risk of tumor lysis syndrome during ramp-up and of neutropenia and other toxicity afterward.
How serious is the interaction between Posaconazole and Venetoclax?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use during venetoclax initiation and ramp-up. After ramp-up, reduce the venetoclax dose per labeling (substantially) and monitor for toxicity and blood counts.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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