Interazioni tra farmaci
Methotrexate + Probenecid
Gravità: Maggiore
Methotrexate and Probenecid: major interaction.
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Sintesi
Probenecid reduces the renal elimination of methotrexate, leading to higher and more prolonged methotrexate concentrations. This can cause severe myelosuppression, mucositis and renal or hepatic toxicity, particularly at higher methotrexate doses.
Cosa significa questa interazione in parole semplici
Methotrexate and Probenecid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Methotrexate belongs to Oncology; Probenecid belongs to Genitourinary.
Perché avviene
Probenecid inhibits organic anion transporters (OAT1/OAT3) in the renal tubule, blocking tubular secretion of methotrexate and its metabolites.
Cosa fare
Avoid the combination where possible; if it is unavoidable, reduce the methotrexate dose and monitor blood counts, renal function and methotrexate levels closely.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Methotrexate
- Acitretin + Methotrexate Controindicata
- Adenovirus types 4 and 7 live + Methotrexate Controindicata
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Controindicata
- Ketorolac + Methotrexate Controindicata
- Measles mumps and rubella vaccine live + Methotrexate Controindicata
- Measles mumps and rubella vaccine + Methotrexate Controindicata
Altre interazioni di Probenecid
- Ketorolac intranasal + Probenecid Controindicata
- Ketorolac + Probenecid Controindicata
- Baricitinib + Probenecid Maggiore
- Ceftazidime / avibactam + Probenecid Maggiore
- Pralatrexate + Probenecid Maggiore
- Probenecid + Roxadustat Maggiore
Domande frequenti
Can I take Methotrexate with Probenecid?
MediHelp rates the interaction as major. Methotrexate and Probenecid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Probenecid reduces the renal elimination of methotrexate, leading to higher and more prolonged methotrexate concentrations. This can cause severe myelosuppression, mucositis and renal or hepatic toxicity, particularly at higher methotrexate doses.
How serious is the interaction between Methotrexate and Probenecid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if it is unavoidable, reduce the methotrexate dose and monitor blood counts, renal function and methotrexate levels closely.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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