Interazioni tra farmaci
Baricitinib + Probenecid
Gravità: Maggiore
Baricitinib and Probenecid: major interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Probenecid inhibits renal organic anion transporter 3, which helps clear baricitinib into urine. Baricitinib exposure rises, which may increase dose-related adverse effects such as infection, cytopenias and lipid changes.
Cosa significa questa interazione in parole semplici
Baricitinib and Probenecid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Baricitinib belongs to Musculoskeletal; Probenecid belongs to Genitourinary.
Perché avviene
Inhibition of OAT3-mediated renal tubular secretion of baricitinib reduces its elimination.
Cosa fare
Baricitinib labeling advises against using it with strong OAT3 inhibitors such as probenecid; if unavoidable, reduce the baricitinib dose as per labeling. Monitor for infection and hematologic abnormalities.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Baricitinib e Probenecid, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Probenecid
- Ketorolac intranasal + Probenecid Controindicata
- Ketorolac + Probenecid Controindicata
- Ceftazidime / avibactam + Probenecid Maggiore
- Methotrexate + Probenecid Maggiore
- Pralatrexate + Probenecid Maggiore
- Probenecid + Roxadustat Maggiore
Altre interazioni di Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Controindicata
- Baricitinib + Bcg vaccine live Controindicata
- Baricitinib + Tofacitinib Controindicata
- Baricitinib + Upadacitinib Controindicata
- Abatacept + Baricitinib Maggiore
- Adalimumab + Baricitinib Maggiore
Domande frequenti
Can I take Baricitinib with Probenecid?
MediHelp rates the interaction as major. Baricitinib and Probenecid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Probenecid inhibits renal organic anion transporter 3, which helps clear baricitinib into urine. Baricitinib exposure rises, which may increase dose-related adverse effects such as infection, cytopenias and lipid changes.
How serious is the interaction between Baricitinib and Probenecid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Baricitinib labeling advises against using it with strong OAT3 inhibitors such as probenecid; if unavoidable, reduce the baricitinib dose as per labeling. Monitor for infection and hematologic abnormalities.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Ceftazidime / avibactam. The full list is on the Probenecid page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
