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Mifepristone + Prednisolone

Gravità: Controindicata

Mifepristone and Prednisolone: contraindicated interaction.

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Sintesi

Mifepristone antagonizes glucocorticoid receptors and can reduce the effect of corticosteroids. In patients on long-term steroid treatment this may cause adrenal insufficiency or loss of disease control, and labeling lists chronic corticosteroid therapy as a contraindication.

Cosa significa questa interazione in parole semplici

Mifepristone and Prednisolone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Mifepristone belongs to Endocrine; Prednisolone belongs to Endocrine.

Livello di evidenza: Moderate

Perché avviene

Mifepristone blocks glucocorticoid receptors, opposing the effect of prednisolone.

Cosa fare

Do not use mifepristone in patients on long-term corticosteroid therapy. Seek specialist advice if both are needed, as standard steroid doses may be ineffective.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Mifepristone with Prednisolone?

MediHelp rates the interaction as contraindicated. Mifepristone and Prednisolone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mifepristone antagonizes glucocorticoid receptors and can reduce the effect of corticosteroids. In patients on long-term steroid treatment this may cause adrenal insufficiency or loss of disease control, and labeling lists chronic corticosteroid therapy as a contraindication.

How serious is the interaction between Mifepristone and Prednisolone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use mifepristone in patients on long-term corticosteroid therapy. Seek specialist advice if both are needed, as standard steroid doses may be ineffective.

What other medicines interact with Prednisolone?

MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.

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