Interazioni tra farmaci
Ozanimod + Safinamide
Gravità: Controindicata
Ozanimod and Safinamide: contraindicated interaction.
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Sintesi
Ozanimod's active metabolites are formed partly via MAO-B, and inhibition may change exposure and could allow nonselective MAO inhibition. Hypertensive crisis is a theoretical risk, and the clinical interaction has not been fully studied.
Cosa significa questa interazione in parole semplici
Ozanimod and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ozanimod belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Perché avviene
MAO-B inhibition alters formation of ozanimod's active metabolites, which may also inhibit MAO, creating a risk of excess adrenergic stimulation.
Cosa fare
Avoid concurrent use as per ozanimod labeling. Allow at least 14 days between stopping one and starting the other.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Safinamide
- Amitriptyline + Safinamide Controindicata
- Amoxapine + Safinamide Controindicata
- Amphetamine polistirex + Safinamide Controindicata
- Clomipramine + Safinamide Controindicata
- Cyclobenzaprine + Safinamide Controindicata
- Desipramine + Safinamide Controindicata
Altre interazioni di Ozanimod
- Isocarboxazid + Ozanimod Controindicata
- Linezolid + Ozanimod Controindicata
- Ozanimod + Phenelzine Controindicata
- Ozanimod + Procarbazine Controindicata
- Ozanimod + Rasagiline Controindicata
- Ozanimod + Tranylcypromine Controindicata
Domande frequenti
Can I take Ozanimod with Safinamide?
MediHelp rates the interaction as contraindicated. Ozanimod and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ozanimod's active metabolites are formed partly via MAO-B, and inhibition may change exposure and could allow nonselective MAO inhibition. Hypertensive crisis is a theoretical risk, and the clinical interaction has not been fully studied.
How serious is the interaction between Ozanimod and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use as per ozanimod labeling. Allow at least 14 days between stopping one and starting the other.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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