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Interazioni tra farmaci

Isocarboxazid + Ozanimod

Gravità: Controindicata

Isocarboxazid and Ozanimod: contraindicated interaction.

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Sintesi

Ozanimod's active metabolites are formed and may inhibit MAO-B, and combining with a nonselective MAOI may raise the risk of hypertensive crisis or serotonin toxicity. Clinical interaction data are limited, but labeling advises against the combination.

Cosa significa questa interazione in parole semplici

Isocarboxazid and Ozanimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Isocarboxazid belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.

Livello di evidenza: Low

Perché avviene

Additive MAO inhibition, with ozanimod metabolites contributing to MAO-B inhibition.

Cosa fare

Do not co-administer; allow at least 14 days between stopping either agent and starting the other.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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  • Additional notes
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Domande frequenti

Can I take Isocarboxazid with Ozanimod?

MediHelp rates the interaction as contraindicated. Isocarboxazid and Ozanimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ozanimod's active metabolites are formed and may inhibit MAO-B, and combining with a nonselective MAOI may raise the risk of hypertensive crisis or serotonin toxicity. Clinical interaction data are limited, but labeling advises against the combination.

How serious is the interaction between Isocarboxazid and Ozanimod?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; allow at least 14 days between stopping either agent and starting the other.

What other medicines interact with Isocarboxazid?

MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.

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