Interazioni tra farmaci
Panobinostat + Quinidine
Gravità: Controindicata
Panobinostat and Quinidine: contraindicated interaction.
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Sintesi
Both drugs prolong the QT interval, so combining them raises the risk of torsades de pointes and sudden cardiac death. Panobinostat labeling advises against use with QT-prolonging drugs.
Cosa significa questa interazione in parole semplici
Panobinostat and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Panobinostat belongs to Oncology; Quinidine belongs to Anti Parasitic.
Perché avviene
Additive blockade of cardiac repolarization potassium channels causes QT prolongation.
Cosa fare
Do not combine. Choose a non-QT-prolonging alternative to quinidine or manage the underlying arrhythmia differently during panobinostat therapy.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Quinidine
- Adagrasib + Quinidine Controindicata
- Arsenic trioxide + Quinidine Controindicata
- Artemether / lumefantrine + Quinidine Controindicata
- Chloroquine + Quinidine Controindicata
- Dofetilide + Quinidine Controindicata
- Dronedarone + Quinidine Controindicata
Altre interazioni di Panobinostat
- Amiodarone + Panobinostat Controindicata
- Anagrelide + Panobinostat Controindicata
- Chloroquine + Panobinostat Controindicata
- Chlorpromazine + Panobinostat Controindicata
- Dronedarone + Panobinostat Controindicata
- Haloperidol + Panobinostat Controindicata
Domande frequenti
Can I take Panobinostat with Quinidine?
MediHelp rates the interaction as contraindicated. Panobinostat and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, so combining them raises the risk of torsades de pointes and sudden cardiac death. Panobinostat labeling advises against use with QT-prolonging drugs.
How serious is the interaction between Panobinostat and Quinidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Choose a non-QT-prolonging alternative to quinidine or manage the underlying arrhythmia differently during panobinostat therapy.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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