医薬品リファレンス
Pamidronate
Pamidronate is a medicine in the class musculoskeletal. It is used for hypercalcemia of malignancy.
- 薬効分類: Musculoskeletal
- 効能・効果: hypercalcemia of malignancy
最終更新日
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要点
- 薬効分類
- Musculoskeletal
- 一般的な剤形
- 注射剤
- 一般的な規格
- 15 mg
- 既知の相互作用
- 9 (中等度: 5 · 軽度: 4)
- 商品名
- 1
- 国・市場
- 1
何に使われるか
作用のしくみ
Bisphosphonate which inhibits bone resorption via actions on osteoclast activity, leading to an indirect increase in bone density
成人の通常用量（添付文書の要約）
Hypercalcemia of Malignancy (Moderate hypercalcemia) (ie, corrected serum calcium 12-13.5 mg/dL): 60-90 mg single-dose IV infusion over 2-24 hours
妊娠と授乳
- 妊娠
- Unsafe No human data on fetal risk. Bisphosphonates enter bone and are released over years; in animals pamidronate caused bone mineralisation defects and embryo-fetal effects. UK label: do not use at any stage of pregnancy unless life-threatening hypercalcaemia cannot be controlled otherwise.
- 授乳
- Unknown Very low milk levels after a 30 mg IV dose, and it is poorly absorbed by mouth. UK label: not recommended (possible bone effects); US: decide on nursing or the drug. LactMed: infant absorption unlikely; withholding feeds for 12-24 h after a dose minimises exposure.
報告されている副作用
- Anemia
- Hypokalemia
- Urinary tract infectious disease
- Hypocalcemia
- Hypomagnesemia
- Hypophosphatemia
禁忌
- Hypersensitivity to drug, other bisphosphonates, or excipients, including mannitol
注意が必要な方
- Bisphosphonates, such as pamidronate disodium, have been associated with renal toxicity, including focal segmental glomerulosclerosis
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (9)
- Aluminum hydroxide + Pamidronate Moderate
- Dichlorphenamide + Pamidronate Moderate
- Foscarnet + Pamidronate Moderate
- Pamidronate + Tenofovir df Moderate
- Pamidronate + Tenofovir disoproxil Moderate
- Calcium + Pamidronate Minor
- Calcium carbonate + Pamidronate Minor
- Entecavir + Pamidronate Minor
- Pamidronate + Teriparatide Minor
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Pamidronateの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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同じ分類のほかの薬剤
よくある質問
What is Pamidronate used for?
Pamidronate is a medicine in the class musculoskeletal. It is used for Hypercalcemia of malignancy, Osteolytic bone lesions of MM, Osteolytic bone metastases of BC, Paget's disease.
What side effects have been reported with Pamidronate?
Anemia, Hypokalemia, Urinary tract infectious disease, Hypocalcemia, Hypomagnesemia, Hypophosphatemia.
Can Pamidronate be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. No human data on fetal risk. Bisphosphonates enter bone and are released over years; in animals pamidronate caused bone mineralisation defects and embryo-fetal effects. UK label: do not use at any stage of pregnancy unless life-threatening hypercalcaemia cannot be controlled otherwise. Breastfeeding: Unknown. Very low milk levels after a 30 mg IV dose, and it is poorly absorbed by mouth. UK label: not recommended (possible bone effects); US: decide on nursing or the drug. LactMed: infant absorption unlikely; withholding feeds for 12-24 h after a dose minimises exposure.
What does Pamidronate interact with?
MediHelp lists 9 known interactions for Pamidronate. Moderate: 5 · Minor: 4. The most serious include Aluminum hydroxide, Dichlorphenamide, Foscarnet.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
