医薬品リファレンス
Rilpivirine
Rilpivirine is a medicine in the class anti virals. It is used for hiv.
- 薬効分類: Anti Virals
- 効能・効果: hiv
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Anti Virals
- ATCコード
- J05AG05
- 一般的な剤形
- 錠剤
- 一般的な規格
- 2.5 mg, 25 mg
- 既知の相互作用
- 111 (併用禁忌: 12 · 重大: 15 · 中等度: 78 · 軽度: 6)
- 商品名
- 4
- 国・市場
- 2
何に使われるか
作用のしくみ
Rilpivirine is an HIV-1 specific non-nucleoside reverse transcriptase inhibitor (NNRTI) antiviral drug.
成人の通常用量（添付文書の要約）
Treatment-naive HIV-1 infection: 25 mg tablet orally once daily with a meal, in combination with other antiretrovirals
妊娠と授乳
- 妊娠
- Unknown APR data show no difference in overall birth defect risk versus background; rilpivirine exposures are lower during pregnancy, so monitor viral load closely.
- 授乳
- Unknown Rilpivirine is present in human breast milk; risks include HIV transmission, viral resistance and adverse reactions in infant.
報告されている副作用
- Depressive disorders
- Headache
- Insomnia
- Rash
- Abdominal pain
- Fatigue
禁忌
- Coadministration with carbamazepine, oxcarbazepine, phenobarbital, phenytoin
- Coadministration with rifampin, rifapentine
- Coadministration with systemic dexamethasone (more than a single dose)
注意が必要な方
- Severe skin and hypersensitivity reactions including DRESS; discontinue immediately if severe rash, fever, blisters, mucosal involvement, angioedema, hepatitis or eosinophilia develop.
- Hepatotoxicity: monitor liver tests, especially with hepatitis B or C co-infection or marked transaminase elevations.
- Depressive disorders including suicidal ideation and suicide attempt; seek immediate medical evaluation for severe symptoms.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (111)
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Pantoprazole + Rilpivirine Contraindicated
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Rilpivirineの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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同じ分類のほかの薬剤
よくある質問
What is Rilpivirine used for?
Rilpivirine is a medicine in the class anti virals. It is used for HIV.
What side effects have been reported with Rilpivirine?
Depressive disorders, Headache, Insomnia, Rash, Abdominal pain, Fatigue.
Can Rilpivirine be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. APR data show no difference in overall birth defect risk versus background; rilpivirine exposures are lower during pregnancy, so monitor viral load closely. Breastfeeding: Unknown. Rilpivirine is present in human breast milk; risks include HIV transmission, viral resistance and adverse reactions in infant.
What does Rilpivirine interact with?
MediHelp lists 111 known interactions for Rilpivirine. Contraindicated: 12 · Major: 15 · Moderate: 78 · Minor: 6. The most serious include Carbamazepine, Dexamethasone, Dexlansoprazole.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
