医薬品リファレンス
Sodium valproate
Sodium valproate is a medicine in the class central nervous system. It is used for epilepsy.
- 薬効分類: Central Nervous System
- 効能・効果: epilepsy
最終更新日
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要点
- 薬効分類
- Central Nervous System
- 別名
- Valproate, Valproic acid
- 一般的な剤形
- 錠剤, シロップ剤, 溶液, カプセル剤, 点滴剤
- 一般的な規格
- 200 mg, 500 mg, 200 mg/ml
- 既知の相互作用
- 9 (重大: 5 · 中等度: 4)
- 商品名
- 39
- 国・市場
- 4
何に使われるか
作用のしくみ
Sodium valproate has a broad spectrum of anticonvulsant activity, but is structurally unrelated to conventional antiepileptic drugs. Its proposed mode of action is mediated through effects on the function of brain gamma-aminobutyric acid (GABA).
成人の通常用量（添付文書の要約）
400-800mg depending on body weight (up to 10mg/kg) followed by continuous or repeated infusion up to a maximum of 2500mg/day.
妊娠と授乳
- 妊娠
- Unsafe Major birth-defect risk (about 1 in 10, incl. neural tube defects) and neurodevelopmental problems in up to 30-40% of exposed children. Contraindicated unless no alternative for epilepsy; never for migraine or (EU) bipolar. Specialist review; pregnancy prevention programme.
- 授乳
- Safe Low levels in milk; usually acceptable. Watch the infant for jaundice, unusual bruising or bleeding; rare cases of low platelets reported.
報告されている副作用
- Vomiting
- Nausea
- Liver injury
- Stomatitis
- Pancreatitis
注意が必要な方
- Pancreatitis, which may be severe and result in fatalities, has been very rarely reported. Patients experiencing nausea, vomiting or acute abdominal pain.
- Patients are advised not to stop valproate medication and to immediately contact a specialist in case of planned or suspected pregnancy.
- Suicidal ideation and behaviour have been reported in patients treated with anti-epileptic agents in several indications.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (9)
- Cannabidiol + Sodium valproate Major
- Fosphenytoin + Sodium valproate Major
- Glycerol phenylbutyrate + Sodium valproate Major
- Sodium phenylbutyrate + Sodium valproate Major
- Sodium valproate + Vorinostat Major
- Ganaxolone + Sodium valproate Moderate
- Rufinamide + Sodium valproate Moderate
- Sapropterin + Sodium valproate Moderate
- Sodium valproate + Telotristat etiprate Moderate
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Sodium valproateの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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同じ分類のほかの薬剤
よくある質問
What is Sodium valproate used for?
Sodium valproate is a medicine in the class central nervous system. It is used for Epilepsy.
What side effects have been reported with Sodium valproate?
Vomiting, Nausea, Liver injury, Stomatitis, Pancreatitis.
Can Sodium valproate be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Major birth-defect risk (about 1 in 10, incl. neural tube defects) and neurodevelopmental problems in up to 30-40% of exposed children. Contraindicated unless no alternative for epilepsy; never for migraine or (EU) bipolar. Specialist review; pregnancy prevention programme. Breastfeeding: Safe. Low levels in milk; usually acceptable. Watch the infant for jaundice, unusual bruising or bleeding; rare cases of low platelets reported.
What does Sodium valproate interact with?
MediHelp lists 9 known interactions for Sodium valproate. Major: 5 · Moderate: 4. The most serious include Cannabidiol, Fosphenytoin, Glycerol phenylbutyrate.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
