相互作用
Glycerol phenylbutyrate + Sodium valproate
重症度: 重大
Glycerol phenylbutyrate and Sodium valproate: major interaction.
最終更新日
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概要
Valproate can cause hyperammonemia and may antagonize the ammonia-lowering effect of glycerol phenylbutyrate in patients with urea cycle disorders. This may precipitate hyperammonemic crises.
この相互作用をわかりやすく説明すると
Glycerol phenylbutyrate and Sodium valproate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glycerol phenylbutyrate belongs to Miscellaneous; Sodium valproate belongs to Central Nervous System.
なぜ起こるのか
Valproate inhibits urea cycle enzyme function (e.g., via carnitine and N-acetylglutamate depletion), raising ammonia.
対処法
Avoid valproate in urea cycle disorders where possible. If used, monitor plasma ammonia closely and adjust the glycerol phenylbutyrate dose.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Glycerol phenylbutyrateとSodium valproateの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Glycerol phenylbutyrateのその他の相互作用
Sodium valproateのその他の相互作用
よくある質問
Can I take Glycerol phenylbutyrate with Sodium valproate?
MediHelp rates the interaction as major. Glycerol phenylbutyrate and Sodium valproate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Valproate can cause hyperammonemia and may antagonize the ammonia-lowering effect of glycerol phenylbutyrate in patients with urea cycle disorders. This may precipitate hyperammonemic crises.
How serious is the interaction between Glycerol phenylbutyrate and Sodium valproate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid valproate in urea cycle disorders where possible. If used, monitor plasma ammonia closely and adjust the glycerol phenylbutyrate dose.
What other medicines interact with Glycerol phenylbutyrate?
MediHelp also lists interactions of Glycerol phenylbutyrate with, for example, Dexamethasone, Valproic acid, Cyclosporin. The full list is on the Glycerol phenylbutyrate page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
