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Telotristat etiprate

Telotristat etiprate is a medicine in the class gastrointestinal tract. It is used for diarrhea.

最終更新日 出典: EMA SmPC

医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。

このページの臨床コンテンツは英語でのみ提供されています。

要点

薬効分類
Gastrointestinal Tract
既知の相互作用
12 (中等度: 10 · 軽度: 2)
商品名
1
国・市場
1

何に使われるか

作用のしくみ

Telotristat ethyl and its active metabolite telotristat inhibit L-tryptophan hydroxylases (TPH1 and TPH2), the rate-limiting steps in serotonin biosynthesis. By inhibiting peripheral TPH1 it reduces serotonin production and eases carcinoid syndrome symptoms.

成人の通常用量（添付文書の要約）

Carcinoid syndrome diarrhoea (with somatostatin analogue therapy, adults inadequately controlled by SSA): 250 mg orally three times daily; higher doses not recommended; reassess benefit if no response within 12 weeks

添付文書の最初の用法・用量の行のみの要約です。用法・用量の全項目はアプリでご覧いただけます。

妊娠と授乳

妊娠
Unknown No human data. No fetal effects in rats at 9 times human exposure; in rabbits fetal loss only with maternal toxicity (15 times), and more early pup deaths in rats at 5 times. EU: not recommended in pregnancy or without contraception. Avoid; use adequate contraception.
授乳
Unknown No human or animal milk data; no LactMed record. EU label: should not be used while breastfeeding (risk cannot be excluded); US label: weigh benefits and watch the infant for constipation. Avoid if possible.

報告されている副作用

  • Abdominal pain
  • Gamma-glutamyl transferase increased
  • Fatigue
  • Abdominal distension
  • Flatulence
  • Constipation

禁忌

  • Hypersensitivity to the active substance or to any excipients.

注意が必要な方

  • Hepatic enzyme elevations: monitor liver enzymes before and during therapy as clinically indicated; discontinue if liver injury is suspected and do not resume unless another cause is found.
  • Constipation: telotristat reduces bowel movement frequency; monitor for constipation and re-evaluate therapy if it develops.
  • Depressive disorders: depression, depressed mood and decreased interest reported; patients should report symptoms.

妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。

主な相互作用 (12)

All 12 interactions, with severity and what to do

Pro+会員向け

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アカウントを作成してPro+トライアルを始めると、Telotristat etiprateの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。

  • Dosing by age, kidney and liver function, and further dose lines
  • Renal and hepatic dose adjustments
  • How to give it
  • Pharmacokinetics
  • Patient counselling points
  • Food interactions
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よくある質問

What is Telotristat etiprate used for?

Telotristat etiprate is a medicine in the class gastrointestinal tract. It is used for Diarrhea.

What side effects have been reported with Telotristat etiprate?

Abdominal pain, Gamma-glutamyl transferase increased, Fatigue, Abdominal distension, Flatulence, Constipation.

Can Telotristat etiprate be taken in pregnancy or while breastfeeding?

Pregnancy: Unknown. No human data. No fetal effects in rats at 9 times human exposure; in rabbits fetal loss only with maternal toxicity (15 times), and more early pup deaths in rats at 5 times. EU: not recommended in pregnancy or without contraception. Avoid; use adequate contraception. Breastfeeding: Unknown. No human or animal milk data; no LactMed record. EU label: should not be used while breastfeeding (risk cannot be excluded); US label: weigh benefits and watch the infant for constipation. Avoid if possible.

What does Telotristat etiprate interact with?

MediHelp lists 12 known interactions for Telotristat etiprate. Moderate: 10 · Minor: 2. The most serious include Bupropion, Capecitabine, Everolimus.

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