相互作用
Prasugrel + Telotristat etiprate
重症度: 中等度
Prasugrel and Telotristat etiprate: moderate interaction.
最終更新日
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概要
Telotristat's metabolite inhibits carboxylesterase 2, which may alter activation of prasugrel, a prodrug hydrolysed by esterases. Antiplatelet effect could be altered, though clinical data are limited.
この相互作用をわかりやすく説明すると
Prasugrel and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prasugrel belongs to Cardiovascular; Telotristat etiprate belongs to Gastrointestinal Tract.
なぜ起こるのか
Carboxylesterase 2 inhibition may alter prodrug hydrolysis of prasugrel.
対処法
Monitor for thrombotic events or bleeding, and consider platelet function testing if clinically concerning.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、PrasugrelとTelotristat etiprateの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Telotristat etiprateのその他の相互作用
Prasugrelのその他の相互作用
よくある質問
Can I take Prasugrel with Telotristat etiprate?
MediHelp rates the interaction as moderate. Prasugrel and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telotristat's metabolite inhibits carboxylesterase 2, which may alter activation of prasugrel, a prodrug hydrolysed by esterases. Antiplatelet effect could be altered, though clinical data are limited.
How serious is the interaction between Prasugrel and Telotristat etiprate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for thrombotic events or bleeding, and consider platelet function testing if clinically concerning.
What other medicines interact with Telotristat etiprate?
MediHelp also lists interactions of Telotristat etiprate with, for example, Bupropion, Capecitabine, Everolimus. The full list is on the Telotristat etiprate page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
