相互作用
Irinotecan + Telotristat etiprate
重症度: 中等度
Irinotecan and Telotristat etiprate: moderate interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Irinotecan is converted to its active metabolite SN-38 by carboxylesterases, and telotristat's metabolite may inhibit CES2. This could reduce activation and efficacy, or alter toxicity, though clinical data are lacking.
この相互作用をわかりやすく説明すると
Irinotecan and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Irinotecan belongs to Oncology; Telotristat etiprate belongs to Gastrointestinal Tract.
なぜ起こるのか
Carboxylesterase 2 inhibition may reduce conversion of irinotecan to SN-38.
対処法
Monitor tumour response and for diarrhoea and neutropenia during co-administration.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、IrinotecanとTelotristat etiprateの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Telotristat etiprateのその他の相互作用
Irinotecanのその他の相互作用
よくある質問
Can I take Irinotecan with Telotristat etiprate?
MediHelp rates the interaction as moderate. Irinotecan and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Irinotecan is converted to its active metabolite SN-38 by carboxylesterases, and telotristat's metabolite may inhibit CES2. This could reduce activation and efficacy, or alter toxicity, though clinical data are lacking.
How serious is the interaction between Irinotecan and Telotristat etiprate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumour response and for diarrhoea and neutropenia during co-administration.
What other medicines interact with Telotristat etiprate?
MediHelp also lists interactions of Telotristat etiprate with, for example, Bupropion, Capecitabine, Everolimus. The full list is on the Telotristat etiprate page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
