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Thalidomide

Thalidomide is a medicine in the class miscellaneous. It is used for multiple myeloma.

最終更新日 出典: US FDA label

医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。

このページの臨床コンテンツは英語でのみ提供されています。

要点

薬効分類
Miscellaneous
ATCコード
L04AX02
一般的な剤形
カプセル剤
既知の相互作用
41 (重大: 9 · 中等度: 29 · 軽度: 3)
商品名
3
国・市場
2

剤形、規格、商品名は国によって異なります。お手元の製品をご確認ください。

何に使われるか

作用のしくみ

Mechanism not fully understood. Acts through cereblon, a component of a cullin ring E3 ubiquitin ligase complex; has immunomodulatory, anti-inflammatory and antiangiogenic properties.

成人の通常用量（添付文書の要約）

Newly diagnosed multiple myeloma (with dexamethasone): 200 mg orally once daily in 28-day cycles, with water, preferably at bedtime and at least 1 hour after the evening meal; dexamethasone 40 mg daily on days 1-4, 9-12 and 17-20 every 28 days

添付文書の最初の用法・用量の行のみの要約です。用法・用量の全項目はアプリでご覧いただけます。

妊娠と授乳

妊娠
Unsafe Contraindicated: a powerful human teratogen; even one dose can cause severe limb, ear, eye, heart and other defects, and about 40% of affected infants die at or soon after birth. Only within a pregnancy-prevention programme: contraception from 4 weeks before to 4 weeks after; men use condoms.
授乳
Unsafe No human milk data; high levels were found in rabbit milk. Because of possible serious reactions in the infant, do not breastfeed during treatment (US label); LactMed: the manufacturer and professional guidelines recommend against breastfeeding.

報告されている副作用

  • Fatigue
  • Hypocalcemia
  • Edema
  • Constipation
  • Sensory neuropathy
  • Dyspnea

警告（枠囲み警告）

  • Embryo-fetal toxicity: can cause severe birth defects or embryo-fetal death, even with a single capsule. Must never be used by females who are or could become pregnant. Exclude pregnancy before treatment and use two reliable contraception methods. Available only through the THALOMID REMS program.

禁忌

  • Pregnancy
  • Demonstrated hypersensitivity to the drug or its components

注意が必要な方

  • Venous and arterial thromboembolism, including ischemic heart disease, MI and stroke, with dexamethasone
  • Increased mortality when pembrolizumab is added to a thalidomide analogue plus dexamethasone in MM; not recommended outside controlled trials
  • Frequent drowsiness and somnolence; avoid hazardous tasks and other sedating drugs

妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。

主な相互作用 (41)

All 41 interactions, with severity and what to do

Pro+会員向け

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アカウントを作成してPro+トライアルを始めると、Thalidomideの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。

  • Dosing by age, kidney and liver function, and further dose lines
  • Renal and hepatic dose adjustments
  • Dosing in older adults
  • How to give it
  • Pharmacokinetics
  • Patient counselling points
  • Food interactions
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同じ分類のほかの薬剤

よくある質問

What is Thalidomide used for?

Thalidomide is a medicine in the class miscellaneous. It is used for Multiple myeloma.

What side effects have been reported with Thalidomide?

Fatigue, Hypocalcemia, Edema, Constipation, Sensory neuropathy, Dyspnea. Serious warning: Embryo-fetal toxicity: can cause severe birth defects or embryo-fetal death, even with a single capsule.

Can Thalidomide be taken in pregnancy or while breastfeeding?

Pregnancy: Unsafe. Contraindicated: a powerful human teratogen; even one dose can cause severe limb, ear, eye, heart and other defects, and about 40% of affected infants die at or soon after birth. Only within a pregnancy-prevention programme: contraception from 4 weeks before to 4 weeks after; men use condoms. Breastfeeding: Unsafe. No human milk data; high levels were found in rabbit milk. Because of possible serious reactions in the infant, do not breastfeed during treatment (US label); LactMed: the manufacturer and professional guidelines recommend against breastfeeding.

What does Thalidomide interact with?

MediHelp lists 41 known interactions for Thalidomide. Major: 9 · Moderate: 29 · Minor: 3. The most serious include Bortezomib, Carbamazepine, Griseofulvin.

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