相互作用
Rifabutin + Thalidomide
重症度: 重大
Rifabutin and Thalidomide: major interaction.
最終更新日
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概要
Rifabutin induces hepatic enzymes, less strongly than rifampicin, and may reduce hormonal contraceptive effectiveness. This is critical in patients on thalidomide because of its teratogenic potential.
この相互作用をわかりやすく説明すると
Rifabutin and Thalidomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Rifabutin belongs to Anti Bacterial; Thalidomide belongs to Miscellaneous.
なぜ起こるのか
Enzyme induction accelerates contraceptive steroid metabolism.
対処法
Use a non-hormonal highly effective method, with a barrier method added, during and after rifabutin treatment.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、RifabutinとThalidomideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Thalidomideのその他の相互作用
Rifabutinのその他の相互作用
よくある質問
Can I take Rifabutin with Thalidomide?
MediHelp rates the interaction as major. Rifabutin and Thalidomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifabutin induces hepatic enzymes, less strongly than rifampicin, and may reduce hormonal contraceptive effectiveness. This is critical in patients on thalidomide because of its teratogenic potential.
How serious is the interaction between Rifabutin and Thalidomide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-hormonal highly effective method, with a barrier method added, during and after rifabutin treatment.
What other medicines interact with Thalidomide?
MediHelp also lists interactions of Thalidomide with, for example, Bortezomib, Carbamazepine, Griseofulvin. The full list is on the Thalidomide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
