相互作用
Phenytoin + Thalidomide
重症度: 重大
Phenytoin and Thalidomide: major interaction.
最終更新日
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概要
Phenytoin induces hepatic enzymes and can reduce hormonal contraceptive levels, leading to contraceptive failure. This is a particular concern with thalidomide because of its serious teratogenicity.
この相互作用をわかりやすく説明すると
Phenytoin and Thalidomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Phenytoin belongs to Central Nervous System; Thalidomide belongs to Miscellaneous.
なぜ起こるのか
Induction of CYP3A4 by phenytoin increases clearance of contraceptive hormones.
対処法
Avoid relying on hormonal contraception alone; use an IUD or other non-hormonal highly effective method plus a barrier method while on phenytoin.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、PhenytoinとThalidomideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Thalidomideのその他の相互作用
Phenytoinのその他の相互作用
よくある質問
Can I take Phenytoin with Thalidomide?
MediHelp rates the interaction as major. Phenytoin and Thalidomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenytoin induces hepatic enzymes and can reduce hormonal contraceptive levels, leading to contraceptive failure. This is a particular concern with thalidomide because of its serious teratogenicity.
How serious is the interaction between Phenytoin and Thalidomide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid relying on hormonal contraception alone; use an IUD or other non-hormonal highly effective method plus a barrier method while on phenytoin.
What other medicines interact with Thalidomide?
MediHelp also lists interactions of Thalidomide with, for example, Bortezomib, Carbamazepine, Griseofulvin. The full list is on the Thalidomide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
