相互作用
Rifampicin + Thalidomide
重症度: 重大
Rifampicin and Thalidomide: major interaction.
最終更新日
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概要
Rifampicin is a strong enzyme inducer that substantially lowers hormonal contraceptive levels, risking contraceptive failure. With thalidomide, a pregnancy would carry a risk of severe birth defects.
この相互作用をわかりやすく説明すると
Rifampicin and Thalidomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Rifampicin belongs to Anti Bacterial; Thalidomide belongs to Miscellaneous.
なぜ起こるのか
Induction of CYP3A4 and other enzymes by rifampicin increases contraceptive hormone metabolism.
対処法
Do not depend on hormonal contraceptives; use a non-hormonal highly effective method such as a copper IUD plus a barrier method during and for several weeks after rifampicin.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、RifampicinとThalidomideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Thalidomideのその他の相互作用
Rifampicinのその他の相互作用
よくある質問
Can I take Rifampicin with Thalidomide?
MediHelp rates the interaction as major. Rifampicin and Thalidomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin is a strong enzyme inducer that substantially lowers hormonal contraceptive levels, risking contraceptive failure. With thalidomide, a pregnancy would carry a risk of severe birth defects.
How serious is the interaction between Rifampicin and Thalidomide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not depend on hormonal contraceptives; use a non-hormonal highly effective method such as a copper IUD plus a barrier method during and for several weeks after rifampicin.
What other medicines interact with Thalidomide?
MediHelp also lists interactions of Thalidomide with, for example, Bortezomib, Carbamazepine, Griseofulvin. The full list is on the Thalidomide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
