相互作用
Phenytoin + Tiratricol
重症度: 中等度
Phenytoin and Tiratricol: moderate interaction.
最終更新日
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概要
Phenytoin induces hepatic enzymes and can accelerate the clearance of thyroid hormones and analogues. Tiratricol effect may be reduced.
この相互作用をわかりやすく説明すると
Phenytoin and Tiratricol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Phenytoin belongs to Central Nervous System; Tiratricol belongs to Endocrine.
なぜ起こるのか
Hepatic enzyme induction (including glucuronidation) by phenytoin increases tiratricol clearance.
対処法
Monitor T3 and clinical thyroid status, and raise the tiratricol dose if needed. Reassess when phenytoin is changed or stopped.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、PhenytoinとTiratricolの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Tiratricolのその他の相互作用
Phenytoinのその他の相互作用
よくある質問
Can I take Phenytoin with Tiratricol?
MediHelp rates the interaction as moderate. Phenytoin and Tiratricol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin induces hepatic enzymes and can accelerate the clearance of thyroid hormones and analogues. Tiratricol effect may be reduced.
How serious is the interaction between Phenytoin and Tiratricol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor T3 and clinical thyroid status, and raise the tiratricol dose if needed. Reassess when phenytoin is changed or stopped.
What other medicines interact with Tiratricol?
MediHelp also lists interactions of Tiratricol with, for example, Levothyroxine, Calcium, Carbamazepine. The full list is on the Tiratricol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
