相互作用
Abiraterone + Daprodustat
重症度: 中等度
Abiraterone and Daprodustat: moderate interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Abiraterone inhibits CYP2C8 and can raise daprodustat exposure, increasing the risk of excessive erythropoiesis and thrombotic events. Daprodustat labeling recommends dose reduction with moderate CYP2C8 inhibitors.
この相互作用をわかりやすく説明すると
Abiraterone and Daprodustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Abiraterone belongs to Endocrine; Daprodustat belongs to Endocrine.
なぜ起こるのか
Abiraterone inhibits CYP2C8, reducing daprodustat metabolism.
対処法
Halve the daprodustat starting dose when initiating with abiraterone unless it is already 1 mg, and monitor hemoglobin to adjust the dose.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AbirateroneとDaprodustatの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Abirateroneのその他の相互作用
Daprodustatのその他の相互作用
よくある質問
Can I take Abiraterone with Daprodustat?
MediHelp rates the interaction as moderate. Abiraterone and Daprodustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Abiraterone inhibits CYP2C8 and can raise daprodustat exposure, increasing the risk of excessive erythropoiesis and thrombotic events. Daprodustat labeling recommends dose reduction with moderate CYP2C8 inhibitors.
How serious is the interaction between Abiraterone and Daprodustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Halve the daprodustat starting dose when initiating with abiraterone unless it is already 1 mg, and monitor hemoglobin to adjust the dose.
What other medicines interact with Abiraterone?
MediHelp also lists interactions of Abiraterone with, for example, Radium-223 dichloride, Thioridazine, Amobarbital. The full list is on the Abiraterone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
