相互作用
Daprodustat + Deferasirox
重症度: 中等度
Daprodustat and Deferasirox: moderate interaction.
最終更新日
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概要
Deferasirox inhibits CYP2C8 to a moderate degree, and daprodustat is cleared mainly by CYP2C8. Exposure to daprodustat can rise, with a greater erythropoietic response and the risk of excessive hemoglobin increases.
この相互作用をわかりやすく説明すると
Daprodustat and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daprodustat belongs to Endocrine; Deferasirox belongs to Miscellaneous.
なぜ起こるのか
Deferasirox inhibits CYP2C8-mediated metabolism of daprodustat.
対処法
Halve the daprodustat starting dose when it is started with deferasirox, unless the starting dose is already 1 mg. Monitor hemoglobin and adjust the dose when deferasirox is started or stopped.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DaprodustatとDeferasiroxの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Deferasiroxのその他の相互作用
Daprodustatのその他の相互作用
よくある質問
Can I take Daprodustat with Deferasirox?
MediHelp rates the interaction as moderate. Daprodustat and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox inhibits CYP2C8 to a moderate degree, and daprodustat is cleared mainly by CYP2C8. Exposure to daprodustat can rise, with a greater erythropoietic response and the risk of excessive hemoglobin increases.
How serious is the interaction between Daprodustat and Deferasirox?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Halve the daprodustat starting dose when it is started with deferasirox, unless the starting dose is already 1 mg. Monitor hemoglobin and adjust the dose when deferasirox is started or stopped.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
