相互作用
Alogliptin-pioglitazone + Daprodustat
重症度: 中等度
Alogliptin-pioglitazone and Daprodustat: moderate interaction.
最終更新日
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概要
Pioglitazone is a weak CYP2C8 inhibitor, whereas daprodustat is a CYP2C8 substrate whose exposure rises with strong inhibitors such as gemfibrozil. A modest increase in daprodustat levels is possible, which could increase hemoglobin and thrombotic risk.
この相互作用をわかりやすく説明すると
Alogliptin-pioglitazone and Daprodustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alogliptin-pioglitazone belongs to Endocrine; Daprodustat belongs to Endocrine.
なぜ起こるのか
Inhibition of CYP2C8-mediated daprodustat metabolism.
対処法
Monitor hemoglobin and adjust the daprodustat dose accordingly when pioglitazone is started or stopped.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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アカウントを作成してPro+トライアルを始めると、Alogliptin-pioglitazoneとDaprodustatの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Alogliptin-pioglitazoneのその他の相互作用
Daprodustatのその他の相互作用
よくある質問
Can I take Alogliptin-pioglitazone with Daprodustat?
MediHelp rates the interaction as moderate. Alogliptin-pioglitazone and Daprodustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pioglitazone is a weak CYP2C8 inhibitor, whereas daprodustat is a CYP2C8 substrate whose exposure rises with strong inhibitors such as gemfibrozil. A modest increase in daprodustat levels is possible, which could increase hemoglobin and thrombotic risk.
How serious is the interaction between Alogliptin-pioglitazone and Daprodustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and adjust the daprodustat dose accordingly when pioglitazone is started or stopped.
What other medicines interact with Alogliptin-pioglitazone?
MediHelp also lists interactions of Alogliptin-pioglitazone with, for example, Gemfibrozil, Insulin aspart, Insulin degludec. The full list is on the Alogliptin-pioglitazone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
