相互作用
Clopidogrel + Daprodustat
重症度: 中等度
Clopidogrel and Daprodustat: moderate interaction.
最終更新日
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概要
The acyl glucuronide metabolite of clopidogrel inhibits CYP2C8, the main enzyme that clears daprodustat. Exposure to daprodustat can rise, with a greater risk of excessive hemoglobin response and related adverse effects such as thrombotic events.
この相互作用をわかりやすく説明すると
Clopidogrel and Daprodustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Daprodustat belongs to Endocrine.
なぜ起こるのか
Inhibition of CYP2C8-mediated metabolism of daprodustat by clopidogrel and its glucuronide metabolite.
対処法
Reduce the daprodustat starting dose as per labeling for moderate CYP2C8 inhibitors. Monitor hemoglobin and adjust the dose when clopidogrel is started or stopped.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClopidogrelとDaprodustatの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clopidogrelのその他の相互作用
Daprodustatのその他の相互作用
よくある質問
Can I take Clopidogrel with Daprodustat?
MediHelp rates the interaction as moderate. Clopidogrel and Daprodustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The acyl glucuronide metabolite of clopidogrel inhibits CYP2C8, the main enzyme that clears daprodustat. Exposure to daprodustat can rise, with a greater risk of excessive hemoglobin response and related adverse effects such as thrombotic events.
How serious is the interaction between Clopidogrel and Daprodustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the daprodustat starting dose as per labeling for moderate CYP2C8 inhibitors. Monitor hemoglobin and adjust the dose when clopidogrel is started or stopped.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
