相互作用
Amikacin + Pancuronium
重症度: 重大
Amikacin and Pancuronium: major interaction.
最終更新日
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概要
Amikacin has neuromuscular blocking activity and can intensify and prolong pancuronium-induced paralysis. This may lead to delayed recovery, residual weakness and respiratory depression or apnea.
この相互作用をわかりやすく説明すると
Amikacin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amikacin belongs to Anti Bacterial; Pancuronium belongs to Musculoskeletal.
なぜ起こるのか
Additive neuromuscular blockade through reduced presynaptic acetylcholine release and postsynaptic receptor blockade.
対処法
Monitor neuromuscular function with train-of-four and reduce pancuronium dosing. Keep ventilatory support available until full recovery is confirmed.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmikacinとPancuroniumの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Pancuroniumのその他の相互作用
Amikacinのその他の相互作用
よくある質問
Can I take Amikacin with Pancuronium?
MediHelp rates the interaction as major. Amikacin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amikacin has neuromuscular blocking activity and can intensify and prolong pancuronium-induced paralysis. This may lead to delayed recovery, residual weakness and respiratory depression or apnea.
How serious is the interaction between Amikacin and Pancuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four and reduce pancuronium dosing. Keep ventilatory support available until full recovery is confirmed.
What other medicines interact with Pancuronium?
MediHelp also lists interactions of Pancuronium with, for example, Bacitracin-neomycin-polymyxin, Capreomycin, Clindamycin. The full list is on the Pancuronium page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
