相互作用
Bacitracin-neomycin-polymyxin + Pancuronium
重症度: 重大
Bacitracin-neomycin-polymyxin and Pancuronium: major interaction.
最終更新日
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概要
Polymyxin B and neomycin can add to the neuromuscular blockade of pancuronium. This may prolong paralysis and cause respiratory depression or delayed recovery. The risk is mainly with systemic or irrigation use, not small topical areas.
この相互作用をわかりやすく説明すると
Bacitracin-neomycin-polymyxin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bacitracin-neomycin-polymyxin belongs to Anti Bacterial; Pancuronium belongs to Musculoskeletal.
なぜ起こるのか
Additive pharmacodynamic neuromuscular blockade through reduced presynaptic acetylcholine release and postsynaptic receptor effects.
対処法
Avoid systemic, irrigation or large-area combination antibiotic exposure during neuromuscular blockade where possible. If used, monitor neuromuscular function with train-of-four and ensure ventilatory support is available.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Bacitracin-neomycin-polymyxinとPancuroniumの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Bacitracin-neomycin-polymyxinのその他の相互作用
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Bacitracin-neomycin-polymyxin 重大
- Atracurium + Bacitracin-neomycin-polymyxin 重大
- Bacitracin-neomycin-polymyxin + Capreomycin 重大
- Bacitracin-neomycin-polymyxin + Cidofovir 重大
- Bacitracin-neomycin-polymyxin + Cisatracurium 重大
- Bacitracin-neomycin-polymyxin + Rocuronium 重大
Pancuroniumのその他の相互作用
よくある質問
Can I take Bacitracin-neomycin-polymyxin with Pancuronium?
MediHelp rates the interaction as major. Bacitracin-neomycin-polymyxin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Polymyxin B and neomycin can add to the neuromuscular blockade of pancuronium. This may prolong paralysis and cause respiratory depression or delayed recovery. The risk is mainly with systemic or irrigation use, not small topical areas.
How serious is the interaction between Bacitracin-neomycin-polymyxin and Pancuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic, irrigation or large-area combination antibiotic exposure during neuromuscular blockade where possible. If used, monitor neuromuscular function with train-of-four and ensure ventilatory support is available.
What other medicines interact with Bacitracin-neomycin-polymyxin?
MediHelp also lists interactions of Bacitracin-neomycin-polymyxin with, for example, Allogeneic cultured keratinocytes / fibroblasts in bovine collagen, Atracurium, Capreomycin. The full list is on the Bacitracin-neomycin-polymyxin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
