Drug interactions
Amiodarone + Avatrombopag
Severity: Moderate
Amiodarone and Avatrombopag: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits CYP3A4 moderately and may raise avatrombopag exposure. Higher exposure can increase the platelet count response and the risk of thrombotic events.
What this interaction means in plain words
Amiodarone and Avatrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Avatrombopag belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4 (and possibly CYP2C9) metabolism of avatrombopag by amiodarone.
What to do
Follow avatrombopag labeling for a reduced starting dose with moderate dual CYP2C9/3A4 inhibitors in ITP. Monitor platelet counts and adjust the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Avatrombopag
- Amobarbital + Avatrombopag Moderate
- Avatrombopag + Bosentan Moderate
- Avatrombopag + Carbamazepine Moderate
- Avatrombopag + Enzalutamide Moderate
- Avatrombopag + Fluconazole Moderate
- Avatrombopag + Ketoconazole Moderate
Frequently asked questions
Can I take Amiodarone with Avatrombopag?
MediHelp rates the interaction as moderate. Amiodarone and Avatrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits CYP3A4 moderately and may raise avatrombopag exposure. Higher exposure can increase the platelet count response and the risk of thrombotic events.
How serious is the interaction between Amiodarone and Avatrombopag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow avatrombopag labeling for a reduced starting dose with moderate dual CYP2C9/3A4 inhibitors in ITP. Monitor platelet counts and adjust the dose accordingly.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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