相互作用
Amiodarone + Umeclidinium-vilanterol
重症度: 重大
Amiodarone and Umeclidinium-vilanterol: major interaction.
最終更新日
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概要
Amiodarone markedly prolongs the QT interval and carries a risk of torsades de pointes. Vilanterol may add to this risk through tachycardia and a fall in potassium.
この相互作用をわかりやすく説明すると
Amiodarone and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Umeclidinium-vilanterol belongs to Respiratory.
なぜ起こるのか
Additive QT prolongation and adrenergic cardiac stimulation.
対処法
Monitor ECG, QTc, potassium and magnesium, and correct any abnormality. Consider an alternative bronchodilator if QTc lengthens significantly.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmiodaroneとUmeclidinium-vilanterolの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Umeclidinium-vilanterolのその他の相互作用
Amiodaroneのその他の相互作用
よくある質問
Can I take Amiodarone with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Amiodarone and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone markedly prolongs the QT interval and carries a risk of torsades de pointes. Vilanterol may add to this risk through tachycardia and a fall in potassium.
How serious is the interaction between Amiodarone and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, QTc, potassium and magnesium, and correct any abnormality. Consider an alternative bronchodilator if QTc lengthens significantly.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amitriptyline, Amoxapine. The full list is on the Umeclidinium-vilanterol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
