相互作用
Amitriptyline + Glycopyrronium
重症度: 中等度
Amitriptyline and Glycopyrronium: moderate interaction.
最終更新日
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概要
Amitriptyline has substantial anticholinergic activity that adds to glycopyrronium. This can cause marked dry mouth, constipation, urinary retention, tachycardia and cognitive impairment.
この相互作用をわかりやすく説明すると
Amitriptyline and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Glycopyrronium belongs to Respiratory.
なぜ起こるのか
Additive antimuscarinic effects at cholinergic receptors.
対処法
Monitor for anticholinergic toxicity, especially in older adults or those with glaucoma or urinary obstruction, and consider an alternative antidepressant or lower doses.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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アカウントを作成してPro+トライアルを始めると、AmitriptylineとGlycopyrroniumの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Glycopyrroniumのその他の相互作用
Amitriptylineのその他の相互作用
よくある質問
Can I take Amitriptyline with Glycopyrronium?
MediHelp rates the interaction as moderate. Amitriptyline and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amitriptyline has substantial anticholinergic activity that adds to glycopyrronium. This can cause marked dry mouth, constipation, urinary retention, tachycardia and cognitive impairment.
How serious is the interaction between Amitriptyline and Glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in older adults or those with glaucoma or urinary obstruction, and consider an alternative antidepressant or lower doses.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
