相互作用
Amphotericin b + Digoxin
重症度: 重大
Amphotericin b and Digoxin: major interaction.
最終更新日
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概要
Amphotericin B often causes hypokalemia and hypomagnesemia, which sensitise the myocardium to digoxin. This can precipitate digoxin toxicity with arrhythmias even at normal serum digoxin levels.
この相互作用をわかりやすく説明すると
Amphotericin b and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amphotericin b belongs to Anti Fungals; Digoxin belongs to Cardiovascular.
なぜ起こるのか
Electrolyte depletion (potassium, magnesium) from amphotericin B increases digoxin cardiac sensitivity.
対処法
Monitor potassium and magnesium frequently and keep them in the normal range with supplements. Check digoxin levels and ECG, and watch for signs of toxicity.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Amphotericin bとDigoxinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amphotericin bのその他の相互作用
Digoxinのその他の相互作用
よくある質問
Can I take Amphotericin b with Digoxin?
MediHelp rates the interaction as major. Amphotericin b and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amphotericin B often causes hypokalemia and hypomagnesemia, which sensitise the myocardium to digoxin. This can precipitate digoxin toxicity with arrhythmias even at normal serum digoxin levels.
How serious is the interaction between Amphotericin b and Digoxin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and magnesium frequently and keep them in the normal range with supplements. Check digoxin levels and ECG, and watch for signs of toxicity.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
