相互作用
Anastrozole + Desogestrel-ethinyl estradiol
重症度: 重大
Anastrozole and Desogestrel-ethinyl estradiol: major interaction.
最終更新日
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概要
Anastrozole works by lowering estrogen levels, and exogenous estrogen such as ethinyl estradiol opposes this effect. The combination undermines the therapeutic aim in hormone-receptor-positive breast cancer, and anastrozole is not intended for use in premenopausal women who might need contraception.
この相互作用をわかりやすく説明すると
Anastrozole and Desogestrel-ethinyl estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anastrozole belongs to Oncology; Desogestrel-ethinyl estradiol belongs to Endocrine.
なぜ起こるのか
Pharmacodynamic antagonism: exogenous estrogen counteracts aromatase inhibition-induced estrogen suppression.
対処法
Avoid combined estrogen-containing products in patients taking anastrozole; use a non-hormonal contraceptive if contraception is needed.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AnastrozoleとDesogestrel-ethinyl estradiolの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Desogestrel-ethinyl estradiolのその他の相互作用
Anastrozoleのその他の相互作用
よくある質問
Can I take Anastrozole with Desogestrel-ethinyl estradiol?
MediHelp rates the interaction as major. Anastrozole and Desogestrel-ethinyl estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Anastrozole works by lowering estrogen levels, and exogenous estrogen such as ethinyl estradiol opposes this effect. The combination undermines the therapeutic aim in hormone-receptor-positive breast cancer, and anastrozole is not intended for use in premenopausal women who might need contraception.
How serious is the interaction between Anastrozole and Desogestrel-ethinyl estradiol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined estrogen-containing products in patients taking anastrozole; use a non-hormonal contraceptive if contraception is needed.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
