相互作用
Amobarbital + Desogestrel-ethinyl estradiol
重症度: 重大
Amobarbital and Desogestrel-ethinyl estradiol: major interaction.
最終更新日
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概要
Barbiturates induce hepatic enzymes and can speed up the metabolism of both ethinyl estradiol and desogestrel's active metabolite. This lowers hormone levels and may cause breakthrough bleeding and contraceptive failure.
この相互作用をわかりやすく説明すると
Amobarbital and Desogestrel-ethinyl estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Desogestrel-ethinyl estradiol belongs to Endocrine.
なぜ起こるのか
Induction of CYP3A4 and other hepatic enzymes increasing clearance of contraceptive steroids.
対処法
Use an alternative non-hormonal or non-enzyme-dependent contraceptive method, such as a copper IUD or DMPA. Continue backup measures for several weeks after stopping the barbiturate.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmobarbitalとDesogestrel-ethinyl estradiolの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Desogestrel-ethinyl estradiolのその他の相互作用
Amobarbitalのその他の相互作用
よくある質問
Can I take Amobarbital with Desogestrel-ethinyl estradiol?
MediHelp rates the interaction as major. Amobarbital and Desogestrel-ethinyl estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates induce hepatic enzymes and can speed up the metabolism of both ethinyl estradiol and desogestrel's active metabolite. This lowers hormone levels and may cause breakthrough bleeding and contraceptive failure.
How serious is the interaction between Amobarbital and Desogestrel-ethinyl estradiol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative non-hormonal or non-enzyme-dependent contraceptive method, such as a copper IUD or DMPA. Continue backup measures for several weeks after stopping the barbiturate.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Anastrozole. The full list is on the Desogestrel-ethinyl estradiol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
