相互作用
Apalutamide + Desogestrel-ethinyl estradiol
重症度: 重大
Apalutamide and Desogestrel-ethinyl estradiol: major interaction.
最終更新日
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概要
Apalutamide is a strong CYP3A4 inducer and can substantially lower exposure to ethinyl estradiol and progestins. This may lead to loss of contraceptive efficacy. Apalutamide is used in men, so the clinical relevance is limited to special situations.
この相互作用をわかりやすく説明すると
Apalutamide and Desogestrel-ethinyl estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Desogestrel-ethinyl estradiol belongs to Endocrine.
なぜ起こるのか
Induction of CYP3A4 (and other enzymes) accelerates metabolism of the contraceptive hormones.
対処法
Avoid reliance on hormonal contraception; use an alternative effective method, with additional barrier protection during treatment.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ApalutamideとDesogestrel-ethinyl estradiolの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Desogestrel-ethinyl estradiolのその他の相互作用
Apalutamideのその他の相互作用
よくある質問
Can I take Apalutamide with Desogestrel-ethinyl estradiol?
MediHelp rates the interaction as major. Apalutamide and Desogestrel-ethinyl estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide is a strong CYP3A4 inducer and can substantially lower exposure to ethinyl estradiol and progestins. This may lead to loss of contraceptive efficacy. Apalutamide is used in men, so the clinical relevance is limited to special situations.
How serious is the interaction between Apalutamide and Desogestrel-ethinyl estradiol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid reliance on hormonal contraception; use an alternative effective method, with additional barrier protection during treatment.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
